Topical acyclovir in herpes zoster ocular involvement.

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Topical acyclovir in herpes zoster ocular involvement.

Topical acyclovir has been found in 15 out of 18 patients to control, without recurrences and in an appreciably shorter time than if steroids were used, keratoconjunctivitis induced by herpes zoster. Once steroids were started, recurrences occurred during withdrawal of steroids or after they had been stopped.

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Oral acyclovir in acute herpes zoster.

Oral acyclovir at a dose of 800 mg five times daily for seven days was compared with placebo in a randomised double blind trial conducted at three centres in the United Kingdom. The study group comprised 205 elderly immune competent patients suffering from herpes zoster who were entered within 72 hours of the onset of rash. Acyclovir significantly reduced the times to arrest of new lesion forma...

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A comparison of topical acyclovir with steroids in the treatment of herpes zoster keratouveitis.

Topical acyclovir has been compared with topical steroids in a coded controlled trial of the treatment of keratouveitis caused by herpes zoster in 40 patients. Topical acyclovir was significantly superior to topical steroids in terms of treatment duration (75 days to 280 days), with no recurrences after the patients were weaned off treatment; there was a 63% recurrence rate in the steroid group...

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Ocular manifestations in herpes zoster ophthalmicus.

BACKGROUND Ocular complications of herpes zoster ophthalmicus (HZO) may lead to substantial visual disability, severe post-herpetic neuralgia and rarely fatal cerebral complications. AIM To identify the pattern of ocular manifestation in herpes zoster ophthalmicus. MATERIALS AND METHODS A cross-sectional descriptive study was under taken including the clinically diagnosed cases of HZO. All ...

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Clinical efficacy and tolerability of valacyclovir versus acyclovir in treatment of herpes zoster

Background: Acyclovir, a specific and selective inhibitor of replication of herpesviridae family, has well documented efficacy for speedy rash healing and decreasing pain of herpes zoster. Limited oral bioavailability of acyclovir requires frequent dosing. Valacyclovir is rapidly and almost completely converted to acyclovir in vivo and gives three to fivefold increase in acyclovir bioavailabili...

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ژورنال

عنوان ژورنال: British Journal of Ophthalmology

سال: 1981

ISSN: 0007-1161

DOI: 10.1136/bjo.65.8.542